MDR1 Dogs and NexGard: Is it Safe?

MDR1 Dogs and NexGard: Is it Safe? info

Short answer: Is Nexgard safe for MDR1 dogs?

According to studies, Nexgard has been shown to be safe for dogs with the MDR1 gene mutation. However, caution should still be exercised and a consultation with a veterinarian is recommended before administering any medication to dogs with known genetic mutations.

Debunking Common Myths: How NexGard is Safe for MDR1 Dogs

For those pet owners who have dogs with MDR1 (multi-drug resistance 1) gene, the idea of any medication can be a worrisome one given their dog’s genetic predisposition to certain toxicities. This often leads to concerns about common flea and tick preventatives, such as NexGard®, which are critical to protecting pets from parasites that are harmful not only to them but also their human families.

However, there’s no need to fret! The truth is that when used as directed, NexGard® is safe for dogs with the MDR1 gene. Here are some common myths surrounding NexGard® for MDR1 dogs – debunked!

Myth #1: Dogs with the MDR1 gene cannot tolerate medicines containing Ivermectin

This myth is mostly true. Some breeds of dogs with the MDR1 mutation are more sensitive to medications containing ivermectin, such as heartworm preventatives or anti-parasitic drugs like Milbemycin Oxime. But the good news is that NexGard® does NOT contain this ingredient.

The active ingredient in NexGard® is Afoxolaner – a new class of anti-parasitic drug called an isoquinoline sulfonamide which has no relation to Ivermectin at all.

Myth #2: All flea and tick preventive treatments should be avoided for MDR1 positive dogs

This myth couldn’t be further from reality. Flea and tick prevention medication helps keep your furry friend not just free but healthy too if done correctly.

With proper dosing recommendations from your vet based on your dog’s individual needs – using FDA-approved flea and tick treatments like NexGard can protect even those pets prone to drug sensitivities such as those identified through advanced DNA screening tests like EmbarkVet or Wisdom Panel V4&5 .

Myth #3: MDR1 positive dogs cannot metabolize flea and tick preventive medication correctly

The MDR1 gene is responsible for producing proteins that help eliminate toxins from a dog’s body. Dogs with the MDR1 gene have a mutation which limits their ability to process certain drugs properly & may exhibit signs of toxicity, like tremors or seizures, if these medications are given at higher doses.

Nevertheless, the active ingredient, Afoxolaner in NexGard® is formulated by industry leaders to break down differently and be safely metabolized even in dogs with compromised detoxification pathways. In clinical studies , there was no difference in safety risks between dogs without the MDR1 mutation compared to those having it when using NexGard as directed.
Consequently, dog owners can rest comfortably knowing that NexGard®’s safety profile is not negatively affected even in dogs predisposed to multiple drug sensitivities such as with the MDR1 gene.

In conclusion

When used as instructed by your veterinarian based on your specific pet’s DNA testing results or breed background and recommended dosages,NexGard® has proven safe for dogs with the MDR1 gene. It’s essential that you discuss any reservations about healthcare options for your dog with your veterinarian proactively. They will guide you on which medications are best suited for your furry friend based on their overall health condition regarding their age, weight & symptoms exhibited.

Don’t let unfounded myths stop you from giving your furry friend the protection they need against fleas and ticks – including those carrying dangerous disease-causing organisms like Lyme Disease or Rocky Mountain spotted fever- just choose NexGard®!

A Step-by-Step Guide: Ensuring the Safety of MDR1 Dogs on NexGard

As a responsible pet owner, it is crucial to ensure that your furry friend’s health and well-being is a top priority. This becomes especially important when dealing with MDR1 (Multi-Drug Resistance 1) dogs who have a genetic mutation that affects the way their bodies process certain drugs, including heartworm preventatives.

One of the most popular heartworm preventatives on the market today is NexGard. However, since MDR1 dogs are known to suffer from adverse reactions to medications such as Ivermectin or Selamectin, it’s important to take some extra precautions whilst administering NexGard to them.

Here’s our step-by-step guide for ensuring the safety of MDR1 dogs while using NexGard:

Step 1: Confirm if your dog has an MDR1 gene mutation
Before you start any treatment program, it’s essential that you confirm whether your dog is carrying the MDR1 gene mutation. A simple DNA test carried out by either your veterinarian or by using an at-home cheek swab kit can provide this information.

Step 2: Choose a safe dosage of NexGard
If your dog tests positive for carrying an MDR1 gene mutation, consult with your veterinarian concerning administering heartworm medication and choose a safe dosage of NexGard based on your dog’s weight and other relevant factors such as age and health status.

Step 3: Monitor closely after administering the dose
Always make sure to monitor closely for any adverse reactions immediately following administration of NexGard in case of nausea, vomiting, diarrhea or other side effects that may occur in response to medication use so you can adjust dosage or seek professional help if needed

Step 4: Take Precautions
Carefully observe precautionary measures while giving your pet its prescribed dose. It ensures minimum risk exposure should there be any negative repercussions due to minor drug sensitivity issues

By following these steps carefully, you’ll be able to keep your MDR1 dog safe while administering NexGard. It’s vital that you adhere closely at every stage and seek professional veterinarian help always when in doubt about any changes’ effects on your pooch.

In conclusion, while NexGard is a proven effective heartworm preventative tool, it’s critical for pet owners of MDR1 dogs to take necessary safety measures to minimise adverse reactions. With our step-by-step guide above, we hope to make this process easier and safer for both you and your furry friend!

FAQ’s About NexGard and MDR1 Dogs: What You Need to Know to Keep Your Pup Safe

As a responsible pet owner, you want to give your furry friend the best possible care. This includes protecting them from parasites such as fleas and ticks. To do so, many people turn to NexGard – a popular flea and tick preventative medication for dogs. However, if you have a dog with the MDR1 gene mutation, there are some important factors to consider before giving them NexGard.

MDR1 (Multi-Drug Resistance 1) is a genetic trait found in certain breeds of dogs, including Australian Shepherds, Border Collies, Shetland Sheepdogs, and many mixed-breeds. Dogs with this mutation have difficulty metabolizing certain drugs which can lead to serious medical issues such as seizures, tremors, and even death.

So what does this mean for using NexGard on MDR1 positive dogs? Here are some frequently asked questions and their answers to help keep your pup safe:

Q: Can MDR1 positive dogs take NexGard?

A: In most cases yes! According to the manufacturer’s website, NexGard is generally safe for use in dogs with the MDR1 mutation. However, it’s crucial to consult with your veterinarian before administering any medication.

Q: How do I know if my dog has the MDR1 gene mutation?

A: A simple DNA test administered by your veterinarian can determine whether or not your dog has the MDR1 gene mutation. If you are unsure if your dog has been tested yet or not, speak with your vet.

Q: Are there any special precautions I should take when giving my MDR1 positive dog NexGard?

A: Yes. It’s recommended that owners of an affected breed start on a lower dose than usual under guidance from their veterinarian. Additionally monitor closely following administration especially during first-time use of the product.

Q: Are there other medications my MDR1 positive dog should avoid besides just NexGard?

A: Yes. Many drugs including some dewormers, pain medications, and heartworm prevention can affect dogs with the MDR1 mutation in potentially harmful ways, so always make sure to consult your veterinarian before starting any new medication.

Ensuring that you’re informed about your dog’s potential health risks is an essential part of being a responsible pet owner. With proper precautions and guidance from your veterinarian, you can safely protect your furry friend from fleas and ticks using NexGard while also keeping them healthy!

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